Cellular Senescence 101

Our bodies are in a constant state of renewal and transformation. Our organs, tissues and the cells within them are subject to regeneration – all at different rates. For instance, the liver renews itself annually, while the skeleton undergoes renewal every ten years. Even our skin, the body's largest organ, rejuvenates approximately every 28 days, which is why you can develop or outgrow allergies over time. Behind this renewal lies the incredible power of stem cells – the drivers of cellular regeneration.

Stem cells are responsible for replenishing dying cells through division, enabling the body to replace aged cells with fresh ones consistently. However, as time goes on, stem cells gradually lose their ability to regenerate efficiently. This process, known as cellular senescence, entails declining stem cell activity and division. The stem cell pool diminishes with age, allowing senescent cells to take the stage.

QUESTION: What are senescent cells?

Cells that are no longer functioning properly, and they don't divide or contribute to the repair and maintenance of your skin like healthy cells do. Instead, they can release harmful substances and cause inflammation, which can lead to various skin issues and accelerate the aging process.

The Unveiling of Senescence

Senescence, characterized by cellular dysfunction and decreased division, marks the beginning of a transformative journey at the cellular level. This process does not halt at individual cells; it spreads through tissues, resulting in the phenomenon we call aging. Senescent cells, which accumulate over time, disrupt tissue function and emit a range of proteins collectively known as the Senescence-messaging-secretome (SMS). These proteins include pro-inflammatory agents and factors that contribute to aging, leading to tissue toxicity and a shift of healthy cells into a senescent state. The scientific community has aptly nicknamed these senescent cells "zombie cells."

The Impact on Skin

The epidermis experiences a weakened barrier function, causing dryness, itching and heightened infection vulnerability. Simultaneously, the dermis witnesses a decline in vital components like Collagen, Elastin and Hyaluronic Acid. This deterioration impairs the skin's mechanical properties, resulting in reduced elasticity and the appearance of wrinkles.

Collaboration & Innovation

Prof. Lemaître, an eminent researcher at INSERM in France, joined forces with the Avène R&D department to explore the complexities of skin aging and develop effective solutions. The result? An innovative range of products: Hyaluron Activ B3.

More than conventional "anti-wrinkle" products, Hyaluron Activ B3 marks a leap forward in addressing the signs of aging. Crafted through a synthesis of research and innovation, these products tackle the root cause of aging while revitalizing cell renewal. The name itself is imbued with meaning:

Hyaluron: Representing Hyaluronic Acid, a sought-after component for addressing wrinkles and enhancing firmness.
Activ: Signifying cell reactivation - a breakthrough that sustains cellular vitality, preventing the onset of senescence.
B3: An homage to Niacinamide, or Vitamin B3, a concentrated ingredient in this line.

The Innovation Unveiled

Hyaluron Activ B3 employs two potent ingredients in tandem to extend cellular longevity.

HYALURON ACTIV B3 Concentrated Plumping Serum is formulated with 6% Niacinamide and 1.5% Hyaluronic Acid to firm and tighten skin immediately.
HYALURON ACTIV B3 Triple Action Eye Cream is formulated with 6% Niacinamide and Hyaluronic Acid to reduce wrinkles, dark circles and puffiness.

Aging, often considered an inevitability, is being redefined by science and innovation. With the Hyaluron Activ B3 range, we offer a holistic approach, promoting youthful skin and a renewed sense of confidence and vitality as we celebrate the synergy of research, collaboration and commitment. A brighter, more youthful future awaits – one where the science of cellular senescence meets the art of ageless beauty.

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